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Table 6 Summarized results of the subgroup analysis

From: Efficacy and safety of mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis

Outcome or subgroup ANC PLT aGVHD cGVHD OS RR NRM
No. of studies Sample size SMD (95% CI) P No. of studies Sample size SMD (95% CI) P No. of studies Sample size RR (95% CI) P No. of studies Sample size RR (95% CI) P No. of studies Sample size HR (95% CI) P No. of studies Sample size RR (95% CI) P No. of studies Sample size OR (95% CI) P
Subtotal 14 471 − 0.77 (− 1.29, − 0.26) < 0.01* 14 538 − 0.66 (− 1.06, − 0.27) < 0.01* 12 475 0.77 (0.64, 0.92) < 0.01* 14 535 0.51 (0.37, 0.70) < 0.01* 10 395 0.88 (0.59, 1.33) 0.54 9 370 0.96 (0.66, 1.41) 0.84 6 197 0.33 (0.16, 0.71) < 0.01*
Type of disease
 Hematologic malignant 10 367 − 0.54 (− 1.14, 0.06) 0.08 9 364 − 0.28 (− 0.61, 0.04) 0.09 8 316 0.77 (0.63, 0.95) 0.02* 9 361 0.51 (0.35, 0.75) < 0.01* 9 381 0.85 (0.56, 1.30) 0.45 9 370 0.96 (0.66, 1.41) 0.84 5 183 0.34 (0.16, 0.73) < 0.01*
 Nonmalignant disorders 1 14 − 2.09 (− 3.47, − 0.70) < 0.01* 2 84 − 1.64 (− 2.15, − 1.14) < 0.01* 2 84 0.83 (0.58, 1.21) 0.34 2 84 0.58 (0.32, 1.06) 0.08 0 0 NA NA 0 0 NA NA 0 0 NA NA
 Mixed 3 90 − 1.39 (− 2.86, 0.07) 0.06 3 90 − 1.41 (− 2.79, − 0.03) 0.05* 2 75 0.53 (0.21, 1.33) 0.17 3 90 0.38 (0.11, 1.28) 0.12 1 14 1.68 (0.27, 10.44) 0.58 0 0 NA NA 1 14 0.27 (0.01, 6.89) 0.43
HLA matching
 Identical 2 88 − 0.79 (− 3.02, 1.45) 0.49 2 134 − 0.94 (− 2.36, 0.49) 0.2 2 94 0.79 (0.56, 1.11) 0.18 3 155 0.43 (0.22, 0.84) 0.01* 2 89 2.95 (1.05, 8.25) 0.04* 2 89 1.34 (0.29, 6.25) 0.71 1 25 0.72 (0.06, 9.22) 0.80
 Non-identical 10 346 − 0.63 (− 1.18, − 0.07) 0.03* 10 367 − 0.50 (− 0.93, − 0.07) 0.02* 10 381 0.76 (0.61, 0.94) 0.01* 10 365 0.56 (0.39, 0.81) < 0.01* 8 306 0.70 (0.45, 1.10) 0.12 6 259 0.81 (0.51, 1.28) 0.37 5 172 0.31 (0.14, 0.68) < 0.01*
 Not reported 2 37 − 1.30 (− 2.03, − 0.57) < 0.01* 2 37 − 1.02 (− 1.77, − 0.26) < 0.01* 0 0 NA NA 1 15 0.16 (0.01, 2.66) 0.20 0 0 NA NA 1 22 3.55 (0.16, 78.56) 0.42 0 0 NA NA
Average age
 ≤ 18 years 8 279 − 1.07 (− 1.84, − 0.31) < 0.01* 7 249 − 0.71 (− 1.22, − 0.19) < 0.01* 6 209 0.64 (0.47, 0.87) < 0.01* 7 276 0.43 (0.23, 0.84) 0.01* 5 175 0.94 (0.39, 2.22) 0.88 5 205 0.79 (0.49, 1.30) 0.36 3 81 0.19 (0.05, 0.68) 0.01*
 > 18 years 6 192 − 0.37 (− 1.00, 0.26) 0.25 6 219 − 0.35 (− 0.86, 0.17) 0.19 5 196 0.85 (0.65, 1.12) 0.25 6 189 0.54 (0.36, 0.81) < 0.01* 5 220 1.01 (0.44, 2.30) 0.98 4 165 1.25 (0.68, 2.31) 0.47 3 116 0.46 (0.18, 1.18) 0.11
 Not reported 0 0 NA NA 1 70 − 1.67 (− 2.22, − 1.11) < 0.01* 1 70 0.86 (0.59, 1.25) 0.42 1 70 0.58 (0.28, 1.21) 0.15 0 0 NA NA 0 0 NA NA 0 0 NA NA
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Stem Cell Research & Therapy

ISSN: 1757-6512

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