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Table 5 Meta-analysis of the safety and efficacy of MSCs co-infused in allo-HSCT

From: Efficacy and safety of mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis

Outcome Study design Number of Trials Sample size SMD/RR/OR/HR 95% CI P I2
ANC RCTs 4 130 SMD, − 1.20 − 2.32, − 0.08 0.04* 86%#
nRCTs 10 341 SMD, − 0.54 − 1.05, − 0.03 0.04* 74%#
PLT RCTs 4 157 SMD, − 0.60 − 1.17, − 0.02 0.04* 63%#
nRCTs 10 381 SMD, − 0.70 − 1.24, − 0.16 0.01* 79%#
aGVHD RCTs 3 98 RR, 0.84 0.59, 1.19 0.33 0%
nRCTs 9 377 RR, 0.74 0.60, 0.91 0.005* 0%
cGVHD RCTs 4 156 RR, 0.53 0.33, 0.87 0.01* 25%
nRCTs 10 380 RR, 0.50 0.33, 0.75 0.001* 0%
OS RCTs 4 164 HR, 1.54 0.81, 2.93 0.18 0%
nRCTs 6 231 HR, 0.60 0.35, 1.02 0.06 34%
RR RCTs 5 186 RR, 1.34 0.74, 2.43 0.34 13%
nRCTs 4 184 RR, 0.74 0.45, 1.22 0.24 0%
NRM RCTs 3 100 OR, 0.59 0.20, 1.73 0.34 0%
nRCTs 3 97 OR, 0.18 0.06, 0.54 0.002* 0%
  1. *The difference was statistical significance
  2. #Significant heterogeneity needed to conduct subgroup analysis
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