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Table 4 Outcomes (immune reconstitution) of included studies

From: Efficacy and safety of mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis

Study Outcome HSCT+MSCs group HSCT group Time points p value
Ball et al. [16] NK cells (× 109/L) 0.497, 95% CI 0.347–0.646 0.252, 95% CI 0.173–0.33 28 days = 0.02*
WBC > 1 × 109/L (days) 11.5, 95% CI 9.0–14.8 14.9, 95% CI 10.1–26.0 NA = 0.009*
NK and T cells NA NA 3 months NS
Liu et al. [22] WBC (days) 12 (10–21) 12 (10–23) NA NS
Ghavamzadeh et al. [33] WBC > 0.5 × 109/L (days) 17.7 (15–20) 17.7 (15–20) NA = 0.83
Mareika et al. [29] (NK) cells (× 109/L) 0.1 (0.02–0.23) 0.01 (0.002–0.06) 100 days = 0.07
B cells (× 109/L) 0.18 (0.11–0.43) 0.07 (0.02–0.19) 100 days = 0.05*
Lee et al. [14] Lymphocyte subpopulations NA NA 28, 100, 180 and 365 days NS
Gonzalo-Daganzo et al. [30] Lymphocyte subpopulations NA NA NA NS
Baron et al. [32] T cells (× 109/L) 0.29 (0.00 4–0.54) 0.202 (0.041–0.886) 28 days NS
Wu et al. [34] Absolute lymphocyte count (× 109/L) 0.305 (0.196–0. 445) 0.256 (0.150–0.368) 30 days = 0.35
Xiang [13] The levels of serum immunoglobulins IgA, IgG, IgM, and IgE 1, 3, and 6 months < 0.05*
The levels of T lymphocytes and B cells
  1. NA not available, NS not significant
  2. *Statistically significant
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