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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Human embryonic stem cell-derived extracellular vesicles alleviate retinal degeneration by upregulating Oct4 to promote retinal Müller cell retrodifferentiation via HSP90

Fig. 6

HSP90 in MVs regulates and interacts with Oct4 in Müller cells. After Müller cells were transfected with sh-NC-MVs, sh-HSP90-MVs, pcDNA3.1-MVs, or pcDNA3.1-HSP90-MVs for 48 h, qRT-PCR (a) and western blot (b) were used for analysis of the mRNA and protein expressions of Oct4, and Co-IP for measurement of the interaction between HSP90 and Oct4 after HSP90 was internalized by Müller cells (c); **P < 0.01, ***P < 0.001; MVs, microvesicles

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Stem Cell Research & Therapy

ISSN: 1757-6512